Highlighted publications
Aspartate aminotransferase Rv3722c governs aspartate-dependent nitrogen metabolism in Mycobacterium tuberculosis
Nature communications – 2020
N-lactoyl-amino acids are ubiquitous metabolites that originate from CNDP2-mediated reverse proteolysis of lactate and amino acids
Proceedings of the National Academy of Sciences of the United States of America – 2015
ABCC6 prevents ectopic mineralization seen in pseudoxanthoma elasticum by inducing cellular nucleotide release
Proceedings of the National Academy of Sciences of the United States of America – 2013
2023
Microbial Metabolomics: An Overview of Applications
In: Soni, V., Hartman, T.E. (eds) Metabolomics. Springer, Cham.
Van der Velden PMM, Jansen RS
The potential role of drug transporters and amikacin modifying enzymes in M. avium
J Glob Antimicrob Resist
Schildkraut JA, Coolen JPM, Ruesen C, van den Heuvel JJMW, Aceña LE, Wertheim HFL, Jansen RS, Koenderink JB, Te Brake LHM, van Ingen J
MS2Query: reliable and scalable MS2 mass spectra-based analogue search
Nature Communications
de Jonge NF, Louwen JJR, Chekmeneva E, Camuzeaux S, Vermeir FJ, Jansen RS, Huber F, van der Hooft JJJ
Peering down the sink: A review of isoprene metabolism by bacteria
Environmental Microbiology
Dawson RA, Crombie AT, Jansen RS, Smith TJ, Nichol T, Murrell C
Candidatus Hydrogenisulfobacillus filiaventi” strain R50 gen. nov. sp. nov., a highly efficient producer of extracellular organic compounds from H2 and CO2
Frontiers in Microbiology
Hogendoorn C, Pol A, de Graaf R, White PB, Mesman R, van Galen PM, van Alen TA, Cremers G, Jansen RS, Jetten MSM, Op den Camp HJM
A new enzymatic assay to quantify inorganic pyrophosphate in plasma
Analytical Bioanalytical Chemistry
Hogendoorn C, Pol A, de Graaf R, White PB, Mesman R, van Galen PM, van Alen TA, Cremers G, Jansen RS, Jetten MSM, Op den Camp HJM
2022
Insect Gut Isolate Pseudomonas sp. Strain Nvir Degrades the Toxic Plant Metabolite Nitropropionic Acid
Applied and Environmental Microbiology
Rogowska-van der Molen MA, Nagornîi D, Coolen S, de Graaf RM, Berben T, van Alen T, Janssen MACH, Rutjes FPJT, Jansen RS, Welte CU
Activity-based annotation: the emergence of systems biochemistry
Trends in Biochemical Sciences
Rhee KY, Jansen RS, Grundner C
An exercise-inducible metabolite that suppresses feeding and obesity
Nature
Li VL, He Y, Contrepois K, Liu H, Kim JT, Wiggenhorn AL, Tanzo JT, Tung AS, Lyu X, Zushin PH, Jansen RS, Michael B, Loh KY, Yang AC, Carl CS, Voldstedlund CT, Wei W, Terrell SM, Moeller BC, Arthur RM, Wallis GA, van de Wetering K, Stahl A, Kiens B, Richter EA, Banik SM, Snyder MP, Xu Y, Long JZ
CinA mediates multidrug tolerance in Mycobacterium tuberculosis
Nature Communications
Kreutzfeldt KM, Jansen RS, Hartman TE, Gouzy A, Wang R, Krieger IV, Zimmerman MD, Gengenbacher M, Sarathy JP, Xie M, Dartois V, Sacchettini JC, Rhee KY, Schnappinger D, Ehrt S
2021
Multiple acyl-CoA dehydrogenase deficiency kills Mycobacterium tuberculosis in vitro and during infection
Nature Commununications
Beites T, Jansen RS, Wang R, Jinich A, Rhee KY, Schnappinger D, Ehrt S
A novel methoxydotrophic metabolism discovered in the hyperthermophilic archaeon Archaeoglobus fulgidus
Environmental Microbiology
Welte CU, de Graaf R, Dalcin Martins P, Jansen RS, Jetten MSM, Kurth JM
2020
Depletion of the DarG antitoxin in Mycobacterium tuberculosis triggers the DNA-damage response and leads to cell death
Molecular Microbiology
Zaveri A, Wang R, Botella L, Sharma R, Zhu L, Wallach JB, Song N, Jansen RS, Rhee KY, Ehrt S, Schnappinger D
The membrane protein ANKH is crucial for bone mechanical performance by mediating cellular export of citrate and ATP
PLoS Genetics
Szeri F, Lundkvist S, Donnelly S, Engelke UFH, Rhee K, Williams CJ, Sundberg JP, Wevers RA, Tomlinson RE, Jansen RS, van de Wetering K
Aspartate aminotransferase Rv3722c governs aspartate-dependent nitrogen metabolism in Mycobacterium tuberculosis
Nature Communications
Jansen RS, Mandyoli L, Hughes R, Wakabayashi S, Pinkham JT, Selbach B, Guinn KM, Rubin EJ, Sacchettini JC, Rhee KY
Dissociation of adaptive thermogenesis from glucose homeostasis in microbiome-deficient mice
Cell Metabolism
Krisko TI, Nicholls HT, Bare CJ, Holman CD, Putzel GG, Jansen RS, Sun N, Rhee KY, Banks AS, Cohen DE
2018
Verapamil targets membrane energetics in Mycobacterium tuberculosis
Antimicrobial Agents and Chemotherapy
Chen C, Gardete S, Jansen RS, Shetty A, Dick T, Rhee KY, Dartois V
2017
Fumarase deficiency causes protein and metabolite succination and intoxicates Mycobacterium tuberculosis
Cell Chemical Biology
Ruecker N, Jansen R, Trujillo C, Puckett S, Jayachandran P, Piroli GG, Frizzell N, Molina H, Rhee KY, Ehrt S
Emerging approaches to tuberculosis drug development: At home in the metabolome
Trends in Pharmacological Sciences
Jansen RS, Rhee K
Metabolic perspectives on persistence
Microbiology Spectrum
Hartman T, Wang Z, Jansen RS, Gardete S, Rhee K
2016
Metabolite profiling of the multiple tyrosine kinase inhibitor lenvatinib: a cross-species comparison
Investigational New Drugs
Dubbelman AC, Nijenhuis CM, Jansen RS, Rosing H, Mizuo H, Kawaguchi S, Critchley D, Shumaker R, Schellens JH, Beijnen JH
MRP1 mediates folate transport and antifolate sensitivity in Plasmodium falciparum
FEBS Letters
Rijpma SR, van der Velden M, Bilos A, Jansen RS, Mahakena S, Russel FG, Sauerwein RW, van de Wetering K, Koenderink JB
2015
ATP-binding Cassette Subfamily C Member 5 (ABCC5) Functions as an efflux transporter of glutamate conjugates and analogs
Journal of Biological Chemistry
Jansen RS, Mahakena S, de Haas M, Borst P, van de Wetering K
N-lactoyl-amino acids are ubiquitous metabolites that originate from CNDP2-mediated reverse proteolysis of lactate and amino acids
Proc Natl Acad Sci U S A
Rijpma SR, van der Velden M, Bilos A, Jansen RS, Mahakena S, Russel FG, Sauerwein RW, van de Wetering K, Koenderink JB
2014
ABCC6-mediated ATP secretion by the liver is the main source of the mineralization inhibitor inorganic pyrophosphate in the systemic circulation
Arteriosclerosis Thrombosis and Vascular Biology
Jansen RS, Duijst S, Mahakena S, Sommer D, Szeri F, Váradi A, Plomp A, Bergen AA, Elferink RP, Borst P, van de Wetering K
2013
ABCC6 prevents ectopic mineralization seen in pseudoxanthoma elasticum by inducing cellular nucleotide release
Proc Natl Acad Sci U S A
Jansen RS, Küçükosmanoglu A, de Haas M, Sapthu S, Otero JA, Hegman IE, Bergen AA, Gorgels TG, Borst P, van de Wetering K